Blood-Brain Barrier Permeation: Molecular Parameters Governing Passive Diffusion
نویسندگان
چکیده
منابع مشابه
Blood Brain Barrier Permeation
The large surface area and the short diffusion distance from capillaries of the blood brain barrier (BBB) to the neurons facilitate the drugs and nutrients access to the brain. Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. Tight junctions regulate the intracellular passage of molecules according to their physicochemical properties (e.g. lipo...
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This review examines the progress that is being made towards the in silico prediction of brain permeation. Following a brief introduction to the blood-brain barrier, the datasets currently available for in silico modeling are discussed. Recent developments in in silico models of brain permeation are summarized in the context of the current state of the art in prediction accuracy. An analysis of...
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The blood-brain barrier (BBB) is a physical interface in the central nervous system (CNS) that exists between the blood and neural tissue. The phenotype of the BBB is primarily the result of the interactions between three main cell types: Endothelial cells, astrocytes, and pericytes [1]. The interactions of the endothelial cells and astrocytes seems to be of utmost importance in maintaining the...
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Exogenous GH can affect central nervous system function when given peripherally to animals and as a supplemental therapy to humans. This study tested whether GH crosses the blood-brain barrier (BBB) by a specific transport system and found that both mice and rats have small but significant uptake of GH into the brain without a species difference. Determined by multiple-time regression analysis,...
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ژورنال
عنوان ژورنال: Journal of Membrane Biology
سال: 1998
ISSN: 0022-2631,1432-1424
DOI: 10.1007/s002329900434